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Two standard artificial strategies were being developed to the preparing of these compounds. The main approach associated the condensation of o-phenylenediamine with phenylacetonitrile to form a 2-benzylbenzimidazole. The benzimidazole is then alkylated with the specified one-chloro-2-dialkylaminoethane, forming the final product or service. This certain course of action was most helpful for that preparing of benzimidazoles that lacked substituents around the benzene rings. A diagram of this process is shown underneath.[

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